يحتوى دواء كماجرا على مادة السيلدينافيل، التي تعالج ضعف الانتصاب عن طريق تأثرها الموسع للأوعية الدموية، فيؤدي إلى انتصاب القضيب عند التحفيز الجنسي.
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تشوه تشريحي في القضيب، مثل التضخم أو التليف أو مرض البايرونيس.
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وجود عوامل تزيد من خطر الإصابة بالانتصاب المستمر، مثل فقر الدم المنجلي، الورم النخاعي المتعدد، وسرطان الدم.
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